Biosense Webster – Health Economics & Outcomes Research

Retrospective Database Studies

Biosense Webster – Health Economics & Outcomes Research

Retrospective Database Studies

Using state-of-the-art medical databases, Biosense Webster, Inc. outcomes research advances our understanding of the treatment of heart rhythm disorders to improve patient outcomes.

The Use of Intracardiac Echocardiography (ICE) Catheters in Endocardial Ablation of Cardiac Arrhythmia: Meta-Analysis of Efficiency, Effectiveness, and Safety Outcomes 

Goya, Masahiko, et al.  J Comp Eff Res. January 2020. doi: 10.1111/jce.14367 

target

Objective

Compare use of ICE during catheter ablation of cardiac arrhythmias affect outcomes compared to ablation without the use of ICE

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Methods

  • Systematic literature review and meta-analysis
  • 19 studies identified
  • 2,186 total patients included
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Results

Use of ICE was associated with a significant:

  • 6.95 mean reduction in fluoroscopy time
  • 15.2 mean reduction in procedure time
  • Reduction in fluoroscopy dose

Predictors of Cardiac Perforation with Catheter Ablation of Atrial Fibrillation 

Friedman, Daniel, et al. JACC EP. March 2020. DOI:10.1016/j.jacep.2020.01.011 

target

Objective

Identify factors associated with the occurrence of cardiac perforation caused during a catheter ablation procedure for atrial fibrillation

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Methods

  • Retrospective, observational cohort study 

  • Data from the Medicare Standard Analytic File was used 

  • Logistic regression was used to assess predictors of cardiac perforation 

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Results

  • 1.3x greater odds of perforation for female sex
  • 1.4x greater odds of perforation for obesity
  • 4.9x lower odds of perforation with use of ICE
  • 0.1x lower odds of perforation with prior cardiac surgery

Real-world Outcomes of Ventricular Tachycardia Catheter Ablation with Versus Without Intracardiac Echocardiography 

Field ME, Gold MR, Reynolds MR, et al. J Cardiovasc Electrophysiol. 2019 Dec 23 doi:10.1111/jce.14324

target

Objective

Assess differences in outcomes between ventricular tachycardia (VT) patients undergoing catheter ablation with versus without the use of intracardiac echocardiography (ICE).

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Methods

  • Retrospective, observational cohort study
  • Data from the IBM MarketScan Commercial and Medicare Supplemental databases were used
  • Comparison using propensity-score matching and regression analysis
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Results

As compared to the non-ICE cohort, at 12-month follow-up, the ICE cohort was associated with:

  • 24% lower odds of VT-related readmission
  • 30% lower odds of repeat VT ablation

Catheter Ablation of Atrial Fibrillation with and Without On-Site Cardiothoracic Surgery 

Friedman, Daniel J et al. J Am Coll Cardiol. 2019 May 21. doi:10.1016/j.jacc.2019.02.036

target

Objective

Assess the relationship between the presence or absence of on-site cardiothoracic surgery (CTS) units, with 30-day rates of cardiac perforation, CTS, re-hospitalization, and death

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Methods

  • Retrospective, non-randomized database study
  • Data from the Medicare Standard Analytic File was used
  • Comparison using propensity-score matching and regression analysis
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Results

There was no significant difference between the presence or absence of CTS units and rates of cardiac perforation, CTS, re-hospitalization, and death.

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