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Coated VICRYL® Plus Antibacterial (polyglactin 910) Suture
Coated VICRYL® Plus Antibacterial (polyglactin 910) Suture
VICRYL Plus Sutures offer smooth tissue passage, exceptional handling, and knot security, and they are shown in vitro to inhibit bacterial colonization of the suture. They provide 2-4 weeks of tissue support.1
Features & Benefits
Shown to reduce SSI risk, supported by Level 1A evidence2,3
Meta-analysis—considered Level 1A evidence3—demonstrated a 28% reduction in surgical site infection (SSI) risk with the use of triclosan-coated sutures.2*† In the same study, meta-regression analysis demonstrated that the effect of triclosan-coated sutures in reducing the risk of SSI did not vary by CDC wound classification or suture type.2,13,*†
A cost-effective part of an SSI-prevention bundle
A single SSI can cost up to $39,000.5,14 But, at up to $5 more per surgery than traditional sutures,4|| Plus Sutures are an affordable part of the SSI-prevention care bundle recommended by the World Health Organization (WHO).6,15
Recommended by 6 independent authorities15
Triclosan-coated sutures are included in SSI-prevention bundles recommended by the CDC, ACS/SIS, WHO, NICE, and RKI.6-10
Explore advanced wound closure technology
With the goal of improving outcomes, Ethicon offers STRATAFIX™ Knotless Tissue Control Devices for more wound-holding security than interrupted suturing, without knot-related complications,11,16 and DERMABOND® PRINEO® Skin Closure System, which was associated with better cosmesis than conventional suturing in a clinical study.12**
Resources
Supporting Documentation
Product Support
Plus Antibacterial Sutures Portfolio Overview
Plus Antibacterial Suture Conversion Chart
Clinical Evidence
Plus Sutures Evidence Summary
Plus Sutures de Jonge Meta-Analysis Overview
References
*21 RCTs, 6462 patients, 95% CI: (14, 40%), P<0.001.
**Measured by the Hollander Cosmesis Scale at 2 weeks after surgery and the Vancouver Scar Scale 6 and 12 months after surgery in a prospective, randomized controlled trial (N=60).
†All triclosan-coated sutures in these RCTs were Ethicon Plus Antibacterial Sutures (MONOCRYL® Plus Antibacterial [poliglecaprone 25] Suture, Coated VICRYL® Plus Antibacterial [polyglactin 910] Suture, and PDS® Plus Antibacterial [polydioxanone] Suture).
||On average, compared to traditional sutures.
1. Ethicon Wound Closure Manual. 2013. Ethicon, Inc.
2. de Jonge SW, Atema JJ, Solomkin JS, Boermeester MA. Meta-analysis and trial sequential analysis of triclosan-coated sutures for the prevention of surgical-site infection. Br J Surg. 2017;104(2):e118-e133.
3. Oxford Centre for Evidence-based Medicine. Levels of Evidence. March, 2009. https://www.cebm.net/2009/06/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/. Accessed September 8, 2020. 4. Plus Suture Cost Analysis. 2019. Ethicon, Inc.
5. de Lissovoy G, Pan F, Paktar A, et al. Surgical site infection incidence and burden assessment using multi-national real-world data. Presented at EU ISPOR Meeting; November 5-8, 2011; Madrid, Spain.
6. World Health Organization Global Guidelines for the Prevention of Surgical Site Infection, 2018. https://apps.who.int/iris/bitstream/handle/10665/277399/9789241550475-eng.pdf. Accessed May 9, 2020.
7. Berríos-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. 2017;152(8):784-791. doi:10.1001/jamasurg.2017.0904.
8. Ban KA, Minei JP, Laronga C, et al. American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update. J Am Coll Surg. 2016;224(1):59-74.
9. National Institute for Health and Care Excellence (NICE) Guideline. Surgical site infections: prevention and treatment. NICE website. https://www.nice.org.uk/guidance/ng125/chapter/Recommendations#closure-methods. Accessed July 2, 2020.
10. Prevention of postoperative wound infections. Recommendation of the Committee for Hospital Hygiene and Infection Prevention (KRINKO) at the Robert Koch Institute. Bundesgesundheitsbl. 2018; 61(4):448-473.
11. Overaker D. Tissue gapping under tension of porcine cadaveric skin incisions closed with Stratafix Spiral in comparison to Monocryl in both interrupted and continuous stitching patterns. August 23, 2012. Ethicon, Inc.
12. Parvizi D, Friedl H, Schintler MV, et al. Use of 2‐octyl cyanoacrylate together with a self‐adhering mesh (Dermabond Prineo) for skin closure following abdominoplasty: an open, prospective, controlled, randomized, clinical study. Aesthetic Plast Surg. 2013;37(3):529‐537.
13. Clean wounds 10 RCTs, 2842 patients 95% CI: (11-43%), P=0.003; non-clean wounds 14 RCTs, 3620 patients, 95% CI: (7-42%).
14. As shown in coronary artery bypass surgery.
15. Guidelines on reducing the risk of surgical site infections are general to triclosan-coated sutures and are not specific to any one brand.
16. In preclinical studies ex vivo model.
© Ethicon US, LLC. 2019.
For complete indications, contraindications, warnings, precautions, and adverse reactions, please reference full package insert.
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