WOUND CLOSURE
DERMABOND™ PRINEO™ Skin Closure System
Product Codes:
CLR222US, CLR422US, CLR602USWOUND CLOSURE
DERMABOND™ PRINEO™ Skin Closure System
Product Codes:
CLR222US, CLR422US, CLR602USDERMABOND PRINEO System combines a liquid adhesive with a self-adhering mesh (latex free) for closure of surgical incisions and simple lacerations. It is a non-invasive alternative to skin sutures and staples. DERMABOND PRINEO combines the proven strength, flexibility, and microbial barrier of DERMABOND ADVANCED™ with the security of a self-adhering mesh to facilitate skin closure and an optimal healing environment.A1-7 In a clinical study, DERMABOND PRINEO System was associated with a better cosmetic outcome than conventional suturing in skin closure. B8
DERMABOND PRINEO System combines a liquid adhesive with a self-adhering mesh (latex free) for closure of surgical incisions and simple lacerations. It is a non-invasive alternative to skin sutures and staples. DERMABOND PRINEO combines the proven strength, flexibility, and microbial barrier of DERMABOND ADVANCED™ with the security of a self-adhering mesh to facilitate skin closure and an optimal healing environment.A1-7 In a clinical study, DERMABOND PRINEO System was associated with a better cosmetic outcome than conventional suturing in skin closure. B8
About this Device
DERMABOND™ PRINEO™ Skin Closure System is a sterile, liquid topical skin adhesive. It also incorporates a self-adhering mesh that is applied to the approximated skin edges to provide temporary skin edge alignment until the liquid adhesive is applied to achieve skin closure. It forms a strong, flexible, waterproof microbial barrier—as long as the adhesive film remains intact—that falls off naturally after 7-14 days.4
Economic Outcomes
In a retrospective study comparing TJA patients with conventional closure to those who had multilayer watertight closure with STRATAFIX™ Knotless Tissue Control Devices and DERMABOND PRINEO Skin Closure System, statistically significant advantages were shown for multilayer watertight closure patients includingC9:
- Shorter LOS (0.5 days)
- No reoperations within 90 days
- Higher percent of patients discharged to home
- Extended time to readmission
Proven Cost Savings
In a retrospective cohort study comparing DERMABOND PRINEO System vs. skin sutures with waterproof closure following sternotomy for cardiac surgery, DERMABOND PRINEO System was associated withD10:
- 1.4 days shorter length of stay
- $10,000 lower total hospital costs
Features & Benefits

Stronger Closure
DERMABOND PRINEO is ~33% stronger than skin staplesEF11 and ~40% stronger than subcuticular 4-0 suture.G11,12

Reduced SSI Risk
DERMABOND PRINEO protects invasions with a watertight, microbial barrier. It provides a flexible microbial barrier with 99% protection in vitro for 72 hours against organisms responsible for SSIs.H5,13

Better Cosmesis
While sutures and staples penetrate the skin and place tension on the wounded tissue, DERMABOND PRINEO System redistributes tension across the surrounding healthy skin in a uniform way which results in improved cosmetic results compared to conventional suturing.J8
Device Specifications and Comparisons
Device Specifications and Comparisons
DERMABOND™ PRINEO™ System is intended for topical application only to hold closed easily approximated skin edges of wounds from surgical incisions, including punctures from minimally invasive surgery, and simple, thoroughly cleansed, trauma-induced lacerations. DERMABOND™ PRINEO™ System should be used in conjunction with, but not in place of, deep dermal stitches. Additionally, the adjunct wound closure device component maintains temporary skin edge alignment along the length of the wound during application of the liquid adhesive.
Select Competitive Products: Exofin® Fusion Skin Closure System
Featured Product |
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DERMABOND™ PRINEO™ Skin Closure System |
DERMABOND™ ADVANCED™ and Mini Topical Skin Adhesives |
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Codes |
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Sizes Available |
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Adhesive Volume |
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Formulation |
Mesh, Highly purified 2-OCA monomer |
Highly purified 2-OCA monomer |
Application |
Single layer over mesh |
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Drying Time |
60 seconds |
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Microbial Barrier |
Yes |
Yes |
Quantity per Box |
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Supporting Documentation
Evidence Resources
Product Resources
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DERMABOND PRINEO Optimized Device Performance Guide
View PDF
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DERMABOND PRINEO FAQ
View PDF
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DERMABOND PRINEO Postoperative Care Overview
View PDF
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DERMABOND PRINEO Port-Site Closure Overview
View PDF
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DERMABOND PRINEO Quick Tips and Application Guide
View PDF
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DERMABOND PRINEO Skin Closure System IFU
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DERMABOND PRINEO 22cm Skin Closure System IFU
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DERMABOND PRINEO 42cm Skin Closure System IFU
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DERMABOND PRINEO 510(k)
View 510(k)
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