DERMABOND™ PRINEO™ Skin Closure System
The DERMABOND™ PRINEO™ Skin Closure System offers a powerful, non-invasive alternative to traditional skin sutures and staples. It offers strong, protected closure for optimal wound healing1-3 and protects against bacteria penetration.1A-C In a clinical study, the DERMABOND™ PRINEO™ System was associated with a better cosmetic outcome than conventional suturing in skin closure.4D
.png?width=3840&quality=90&format=webp)
.png?width=3840&quality=90&format=webp)
.png?width=3840&quality=90&format=webp)
.png?width=3840&quality=90&format=webp)
About this device
DERMABOND™ PRINEO™ Skin Closure System is a sterile, liquid topical adhesive paired with a self-adhering mesh. It is applied to the approximated skin edges to provide temporary skin edge alignment until the liquid adhesive is applied to achieve skin closure.5 It remains intact for 7–14 days before naturally falling off.5 Patients treated with DERMABOND™ PRINEO™ were associated with 29% fewer wound infections compared with standard closure methods.6E
Specialties
Orthopaedic, OBGYN, Breast, Cardiovascular, Spine
Procedures
Total Knee Arthroplasty, Total Hip Arthroplasty, Abdominoplasty, Breast, Reconstruction, CABG, Valve Replacement
Economic benefits
In a retrospective study comparing DERMABOND™ PRINEO™ Skin Closure System to skin staples and wound dressings in C-Section procedures, DERMABOND™ PRINEO™ was associated with7:
- $434 of total hospital cost savings, per patientF
- 5% reduction in length of stay
Proven cost savings
In a retrospective cohort study comparing DERMABOND™ PRINEO™ Skin Closure System vs. skin sutures with waterproof closure following sternotomy for cardiac surgery, DERMABOND™ PRINEO™ was associated with8G:
- 1.4 days shorter length of stay
- $10,000 lower total hospital costs
Features & benefits
Strong closure
DERMABOND™ PRINEO™ offers strong, protected closure for optimal wound healing.1-3
Protection
DERMABOND™ PRINEO™ provides a flexible microbial barrier with 99% protection in vitro for 72 hours against organisms responsible for SSIs.9C
.png?width=3840&quality=90&format=webp)
Improved cosmesis
While sutures and staples penetrate the skin and place tension on the wounded tissue, DERMABOND™ PRINEO™ redistributes tension across the surrounding healthy skin in a uniform way, which results in improved cosmetic results compared to conventional suturing.10D
Learn how to use this device
Supporting documentation
Related products
DERMABOND ADVANCED™ Topical Skin Adhesive
DERMABOND ADVANCED™ Topical Skin Adhesive holds wound edges together following surgical incisions and lacerations.¹ It provides a microbial barrier with 99% effectiveness for 72 hours in vitro.2A Patients also benefit from significantly improved comfort and satisfaction when compared to sutured closures.3,4B
References
A. Provided a microbial barrier for 72 hours in an in vitro model.
B. P. aeruginosa, E. coli, E. faecium, S. aureus, and S. epidermidis.
C. Clinical significance unknown.
D. Measured by the Hollander Cosmesis Scale at 2 weeks after surgery and the Vancouver Scar Scale 6 and 12 months after surgery in a prospective, randomized controlled trial (N=60).
E. Based on meta-analysis of 12 studies, 6 evaluated infection rates. 1.51% for DERMABOND™ PRINEO™ vs 2.13% for conventional closure techniques (p=0.01).
F. Based on a retrospective study of 4,266 patients undergoing C-Section in Premier Healthcare Database® (01/2012 – 03/2017).
G. Based on a retrospective study of 10,676 patients undergoing cardiac surgery requiring sternotomy in Premier Healthcare Database® (10/2015 – 06/2020).
- Su W. Study report for in vitro evaluation of microbial barrier properties of DERMABOND ProTape. 06TR071. December 4, 2006. Ethicon, Inc.
- Kumar A. Study to Compare the tissue holding strength of PRINEO™ skin closure system with conventional wound closure techniques. AST-2012-0290. October 11, 2012. Ethicon, Inc.
- Kannon GA, Garrett AB. Moist wound healing with occlusive dressings. Dermatol Surg. 1995;21:583-590.
- Parvizi D, Friedl H, Schintler MV, et al. Use of 2-octyl cyanoacrylate together with a self-adhering mesh (Dermabond Prineo) for skin closure following abdominoplasty: an open, prospective, controlled, randomized, clinical study. Aesthetic Plast Surg. 2013;37(3):529-537.
- DERMABOND™ PRINEO™ Skin Closure System Instructions for Use. Ethicon, Inc.
- Kulkarni S, Goodbun M, Chowdhury M, Stather PW. Dermabond Prineo: a systematic review and meta-analysis. J Wound Care. 2025;34(3):220-226.
- Johnston S, Chen B, Nayek A, et al. Clinical and economic outcomes of cesarean deliveries with skin closure through skin staples plus waterproof wound dressings versus 2-octyl cyanoacrylate plus polymer mesh tape. The Journal of Maternal-Fetal & Neonatal Medicine. 2019
- Ethicon: Clinical and Economic Outcomes after sternotomy for cardiac surgery with skin closure through 2-octyl cyanoacrylate plus polymer mesh tape versus absorbable sutures plus waterproof wound dressings, Q2 2021.
- Bhende S, Rothenburger S, Spangler DJ, Dito M. In vitro assessment of microbial barrier properties of DERMABOND® Topical Skin Adhesive. Surg Infect (Larchmt). 2002;3(3):251-257.
- Parvizi D, Friedl H, Schintler MV, et al. Use of 2-octyl cyanoacrylate together with a self-adhering mesh (Dermabond Prineo) for skin closure following abdominoplasty: an open, prospective, controlled, randomized, clinical study. Aesthetic Plast Surg. 2013;37(3):529-537.
For complete indications, contraindications, warnings, precautions, and adverse reactions, please reference full package insert.
The third-party trademarks used herein are trademarks of their respective owners.
US_SRG_WOUN_117938.2