ECHELON™+ Stapler with GST Reloads
The ECHELON™+ Stapler is a powered laparoscopic stapler with exceptional staple line integrity across the broadest range of tissue thicknesses.1,2A It advances staple line security to deliver fewer leaks at the staple line and better staple formation, even in challenging conditions.3,4B
About this device
The ECHELON™+ Stapler is a powered laparoscopic stapler designed to adapt to varying tissue. Its re-engineered anvil, paired with ECHELON™ Gripping Surface Technology (GST) Reloads, is designed for more uniform compression and less tissue slippage for better staple formation in thick tissue. Dynamic Firing slows the stapler as it engages with thick tissue to enhance compression and audible feedback.3
Specialties
Colorectal, Thoracic, Bariatric, Urologic, General
Procedures
LAR, Colectomy, Lobectomy, Wedge Resection, Segmentectomy, Sleeve Gastrectomy, Gastric Bypass, Revisions
Clinical benefits
The ECHELON™+ Stapler advances staple line security to help reduce complications.
- Fewer leaks at the staple line3C
- Better Staple formation in thick tissue4D
- Associated with a reduction in the rate of hemostasis-related complications5E
- Less tissue movement while firing6F
Compared to Medtronic Signia™ Stapler with Tri-Staple™ Reloads
Real world evidence
Design differences matter when it comes to performance and results. ECHELON™ stapling devices have proven results across varied tissue types, patient populations and countries - in bariatric, thoracic and colorectal procedures. These findings are drawn from approximately 14 peer-reviewed studies covering over 47,000 patients and 700 hospitals, spanning 9 countries and 4 continents.
Associated with improved clinical and economic outcomes5,7,8:
- Reduced clinical complications
- Reduced hospital costs
- Improved efficiency
Features & benefits
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Dynamic firing
Slows as it engages thick tissue to enhance compression and audible feedback.9
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ECHELON™+ Anvil
Designed for more consistent compression and to better capture and form staples10G for significantly fewer leaks at the staple line.3,4B
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ECHELON™ Gripping Surface Technology Reloads
Added more support while firing to produce better staples and reduce tissue movement compared to Tri-Staple™ reloads.4,6H
Learn how to use this device
Supporting documentation
Related products

ECHELON™ 3000 Stapler
The ECHELON™ 3000 Stapler was designed to accommodate each patient's unique anatomy, providing consistency across every staple line. It enables better access1A and more control2B over each transection, making it easier to tailor procedures to your patient's unique needs.

ECHELON FLEX™ Powered Vascular Stapler
In thoracic surgery, tight spaces can limit visibility, control, and access, making it difficult to navigate critical anatomy with confidence. The narrow anvil, increased articulation, and smaller shaft diameter of the ECHELON FLEX™ Powered Vascular Stapler, improved access in VATS procedures, enabling precise placement on fragile pulmonary vessels.1A

ECHELON™ Gripping Surface Technology Reloads
The flexibility to select the right reload for each patient’s unique tissue is critical. With ECHELON™ Gripping Surface Technology (GST) Reloads, you get exceptional staple line integrity—across the broadest range of tissue thicknesses1-5A. For use with the ECHELON™ 3000 Stapler, ECHELON™+ Stapler, or ECHELON FLEX™ ENDOPATH™ Staplers.
References
A. ECHELON FLEX GST System designed and tested to produce well-formed staple lines blocking potential leak paths in tissue thicknesses from 1.0mm to 4.0mm. Porcine tissues measured at 8g/mm2 prior to firing and comfortably compressed during firing per the IFU. vs: Medtronic Tri-Staple portfolio (intended thickness range 0.75mm - 3.0mm [per Medtronic P100154]); and, Intuitive EndoWrist® Stapler portfolio (intended thicknesses range - 0.75mm - 2.0mm [per user manual PN 551681-07 Rev. C 2016.12]).
B. Fewer leaks benchtop testing in porcine tissue ≤ 52mmHg (Double the 26mmHG average pressure experienced during intra-operative leak test), comparing Ethicon ECHELON+ Stapler PSEE60A with GST Reloads GST60B to Medtronic Signia Stapler with Tri-Staple Reloads EGIA60AMT. Cumulative number of leaked tests (14/30), (23/30) respectively, n=30 p < 0.05. Staple formation benchtop testing in 3.3mm and 4.0mm porcine tissue comparing malformed staples between ECHELON+ Stapler with GST Reloads (GST60G,GST60T) to Medtronic Signia™ Stapler with Tri-Staple™ Reloads (EGIA60AMT, EGIA60AXT) and Endo GIA™ with Tri-Staple™ Reloads (EGIA60AMT, EGIA60AXT). Percentage malformed results: 1.14% vs 4.28% respectively, p < 0.05.
C. Benchtop testing in porcine tissue ≤ 30mmHg (26mmHG average pressure experienced during intra-operative leak test), comparing Ethicon ECHELON+ Stapler PSEE60A with GST Reloads GST60B to Medtronic Signia Stapler with Tri-Staple Reloads EGIA60AMT. Cumulative number of leaked tests (0/30) & (7/30) respectively, n=30 p < 0.05.
D. Benchtop testing in 3.3mm and 4.0mm porcine tissue comparing malformed staples between ECHELON+ Stapler with GST Reloads (GST60B,GST60T) to Medtronic Signia™ Stapler with Tri-Staple™ Reloads (EGIA60AMT, EGIA60AXT) and Endo GIA™ with Tri-Staple™ Reloads (EGIA60AMT, EGIA60AXT). Percentage malformed results: 1.14% vs 4.28%, p < 0.05
E. Analysis of clinical and economic outcomes from 982 laparoscopic sleeve gastrectomy cases between March 1, 2017 and December 31, 2018 from Premier Healthcare Database (0.61% versus 2.24%, p=0.0012; $9,771 vs. $10,487, p<0.001)
F. In benchtop testing in porcine stomach tissue, the ECHELON+ Stapler with GST Reloads (PSEE60A, GST60T) had less mean longitudinal change in 4.0mm thick tissue, 0.79mm vs. 4.09mm, compared to the Signia™ Stapling System (SIGPHANDLE, SIG60AXT), p-value <0.05.
G. Designed with wider, tapered anvil pockets and a refined camber compared to predicate ECHELON FLEX™ Powered Stapler.
H. Benchtop testing porcine tissue comparing malformed staples and mean longitudinal change between ECHELON+ Stapler with GST Reloads (GST60G/GST60T), (n= 15, SD=0.1610) to Medtronic Signia™ Stapler with Tri-Staple™ Reloads (EGIA60AMT/EGIA60AXT/SIG60AXT), (n=15, SD=0.2150). Percentage malformed results: 1.14% vs 4.28%. Mean tissue movement results: 0.79mm vs. 4.09mm, p-value <0.05.
- Ethicon, Project Cowbell 60mm SLI-FTC-Cut Length DV Completion Report. 12.11.2020. Windchill Document #PRC095237
- Ethicon, Cowbell 45mm DV Completion Report. 04.14.2020. Windchill Document #PRC093801
- Ethicon, Ex-Vivo Comparison of Staple Line Leak Pressure: Echelon Flex Powered Plus Stapler with GST vs EndoGIA and Signia with Tri-Staple Technology. 08.13.2020. Windchill Document #PRC096436
- Ethicon, Evaluation of Malformed Staples in Thick Tissue for Claims: Echelon Flex Powered Plus Stapler with GST vs EndoGIA and Signia with Tri-Staple Technology. 08.25.2020. Windchill Document #PRC096858
- Rawlins et al,. Comparative Effectiveness Assessment of Two Powered Surgical Stapling Platforms in Laparoscopic Sleeve Gastrectomy: A Retrospective Matched Study. Medical Devices: Evidence and Research. 2020;13: 195–204
- Ethicon, Evaluation of stomach tissue movement during stapler firing for claims: Cowbell vs Signia. 11.13.2020. Windchill Document #PRC097776
- Miller D, Roy S, Kassis E, Yadalam S, Ramisetti S, Johnston S. Impact of Powered and Tissue-Speci?c Endoscopic Stapling Technology on Clinical and Economic Outcomes of Video-Assisted Thoracic Surgery Lobectomy Procedures: A Retrospective, ObservationalStudy. Advances in Therapy. 2018; 35:707-723
- Sylla P, Sagar P, Johnston S, et al. Outcomes associated with the use of a new powered circular stapler for left-sided colorectal reconstructions: a propensity score matching-adjusted indirect comparison with manual circular staplers. Surgical Endoscopy. 2021; 36: 13
- Ethicon, Cowbell Claims - Transection Time Comparison to Roadrunner. 09.18.2020. Windchill Document #PRC097399
- Ethicon, Design Intent for ECHELON+ Anvil (Project Cowbell). 10.27.2020. Memo
For complete indications, contraindications, warnings, precautions, and adverse reactions, please reference full package insert.
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© Johnson & Johnson and its affiliates 2026.
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