Intuitive. Versatile. Reproducible.
The first CARTO™ 3 System-integrated Pulsed Field Ablation (PFA) platform with the VARIPULSE™ Catheter, an intuitive pulmonary vein isolation solution powered by the TRUPULSE™ Generator is here.
The VARIPULSE™ Platform enables efficient, patient-centric therapy delivery with a simple integration. In conjunction with Johnson & Johnson MedTech's fully integrated portfolio, you have a single solution to scale between simple and complex ablations, reducing the complexity of managing your day in the lab.
Pulsed Field Ablation. CARTO™ System integration.
The integrated VARIPULSE™ Platform is designed to deliver ablations at precise locations.*
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Tissue proximity indicator
Through pre-clinical studies, Johnson & Johnson MedTech has demonstrated that contact is important to create consistent lesion depth during the ablation.**
The Tissue Proximity Indicator is designed to visually show the physician the electrodes on the loop that have contact prior, during and after ablation.
** Based on internal benchtop data. TR-0042284
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Pulsed field tag coloring
The VARIPULSE™ Software Module provides automatic 3D visual information about application locations during and after ablation.
Pulsed Field (PF) tag coloring provides application feedback during the ablation and the TPI filter removes tags that were not in proximity to tissue at the beginning of ablation.
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Precise energy delivery
Identification of lesion placement is only part of procedure workflow. There is also a need to identify any areas of the pulmonary vein ostium that have not been ablated.
The VARIPULSE™ Platform is designed to enable precise energy delivery for initial PVI and identification of gaps when needed, providing physicians with the confidence of an accurate CARTO™ ecosystem they know.
Clinically deliver.1,2
The VARIPULSE™ Platform has a proprietary pulse sequence which has been proven in robust preclinical work to have tissue selective properties and preserves the tissue architecture.
Zero
strokes with VARIPULSE™ Platform in patients across US & Europe3,4
85%
peak 12-month3 effectiveness with 24-32 ablations
*admIRE trial n=85. PAF only patients, 1 ablation = 3 applications
63%
of cases done with zero fluoroscopy2
30%
cases performed under conscious sedation6
Integrated platform
VARIPULSE™ Catheter
The VARIPULSE™ Platform full integration may reduce the need for multiple methods of catheter visualization used in one procedure, creating a streamline workflow.
Designed for mapping integration: 3 Single Axis Sensor locations designed for accurate visualization on the CARTO™ 3 System; variable loop size (25mm - 35mm) to adjust to fit the patient’s anatomy
Bi-directional deflection: The VARIPULSE™ Catheter is built on a bi-directional, 8 Fr platform compatible with the CARTO VIZIGO™ Bi-Directional Guiding Sheath or similar 8.5 F inner lumen sheath.
35mm to 25 mm variable loop contraction: 10 electrodes that electro-anatomically map, emit pulsed field for ablation and allow pacing per electrode.
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Enabling power
TRUPULSE™ Generator
The TRUPULSE™ Generator is the cornerstone of your PFA procedures. The system delivers a unique bi-polar, bi-phasic pulse sequence specifically tailored for the VARIPULSE™ Catheter design.
- Automatically detects which catheter is connected and loads the correct pulse sequence
- Maximize lab uptime with field upgradeable software and on-screen troubleshooting
- Connect two touch screen monitors for management from both the operating theatre and the control room
- Control ablation via the foot pedal or the touch screen monitors
- Select from 33 different languages for onscreen display
Supporting with excellence
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Expertise at your side
Our team of clinical specialists have a deep knowledge in every aspect of the mapping technology to complement your team’s skills and offer real-time insights when you need them.
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Training Expertise Centers
We offer a comprehensive site visit program to physicians and fellows who are interested in observing safe and effective utilization of our current technology during complex ablations in a clinical setting.
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Therapy Advancement Program
With a focus on clear and accessible AFib education, insights from physician thought leaders, and compelling patient stories, Get Smart About AFib aims to be a trusted resource where physicians and providers can confidently refer their patients.
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Patient Education Resources
With a focus on clear and accessible AFib education, insights from physician thought leaders, and compelling patient stories, Get Smart About AFib aims to be a trusted resource where physicians and providers can confidently refer their patients.
Supporting documentation
Browse products
References
*Precise in that it is marked on CARTO™ 3 System screen. When used with the CARTO™ 3 System.
- TRUPULSE™ Generator User Manual (Software 2.2.0). EML-1417-01-IFU-B-EN.
Reddy V, et al. Long-term Safety and Effectiveness After Paroxysmal Atrial Fibrillation Pulsed Field Ablation From the U.S. Multicenter admIRE Study. Heart Rhythm Society. Published May 17, 2024.
- Almorad A, Sebag FA, Kronborg MB, et al. Presented at ESC 2025; September 1, 2025. Pending formal publication.
Porterfield C, Krishnan K, Saleem M, Ebinger M, Gampa A, Greenberg J, et al. Heart Rhythm. 2025. doi:10.1016/j.hrthm.2025.10.027
Reddy V, Calkins H, Mansour M, et al. Pulsed field ablation to treat paroxysmal atrial fibrillation: safety and effectiveness in the admIRE pivotal trial. Circulation. Published online September 11, 2024. doi: 10.1161/CIRCULATIONAHA.124.070333.
De Potter T, Grimaldi M, Duytschaever M, et al. Predictors of success for pulmonary vein isolation with pulsed field ablation using a variable loop catheter with 3D mapping integration: complete 12-month outcomes from inspIRE. Circ Arrhythm Electrophysiol. 2024. doi: 10.1161/CIRCEP.123.012667.
Porterfield C, Krishnan K, Saleem M, Ebinger M, Gampa A, Greenberg J, et al. Heart Rhythm. 2025. doi:10.1016/j.hrthm.2025.10.027
Almorad A, Sebag FA, Kronborg MB, et al. Presented at ESC 2025; September 1, 2025. Pending formal publication.
Biosense Webster, Inc.’s products with FDA approved/cleared instructions for use to support fluoro alternative workflows when used with the CARTO™ 3 System include the following: THERMOCOOL SMARTTOUCH™ SF Catheter, THERMOCOOL SMARTTOUCH™ Catheter, VARIPULSE™ Catheter, CARTO™ VIZIGO™ Bi-Directional Guiding Sheath, PENTARAY™ NAV ECO High Density Mapping Catheter, OCTARAY™ Mapping Catheter with TRUEref™ Technology, OPTRELL™ Mapping Catheter with TRUEref™ Technology, DECANAV™ Mapping Catheters, and Webster™ CS Catheter.
Always verify catheter tip location using common clinical practice for real-time verification (inspection of IC signals, direct imaging guidance such as fluoroscopy or ultrasound, etc.) and consult the CARTO™ 3 System User Guide regarding recommendations for fluoroscopy use.
Canpolat, U. et al (2020). State of Fluoroless Procedures in Cardiac Electrophysiology Practice. J Innov Cardiac Rhythm Management. 11(3), 4018–4029. Sommer, P. et al (2018) Safety profile of near-zero fluoroscopy atrial fibrillation ablation with non-fluoroscopic catheter visualization: experience from 1000 consecutive procedures, EP Europace, Volume 20, Issue 12, Pages 1952–1958.
Important information: Prior to use, refer to the instructions for use supplied with this device for indications, contraindications, side effects, warnings and precautions. Caution: US law restricts this device to sale by or on the order of a physician.
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