CONDUIT™ Interbody Platform | EIT™ Cellular Titanium

3D printed cellular titanium implants that feature 80% porous macro-, micro- and nanostructures, are designed to mimic cortical and cancellous bone.^1,2

BONE-MIMICKING CELLULAR TITANIUM MATERIAL – Cellular structure of the material is designed to mimic the published properties of bone.

EXCELLENT VISUALIZATION – Ability to clearly visualize the cage intra- and post-operatively on imaging modalities without interference^3,4

TARGETED MODULUS OF ELASTICITY – Modulus of Elasticity similar to cancellous bone (Figure 1)^5,6

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CONDUIT™ Interbody Platform EIT™ Cellular Titanium Sales Sheet

Features & Benefits

MACROSTRUCTURE

Surface roughness has been shown to have a beneficial effect on cell differentiation and proliferation in in-vitro studies of osteoblast-like cells cultured on similar roughened titanium materials^7,8

MICROSTRUCTURE

In-vitro studies have reported greater osteoblastic differentiation in human stem cells cultured on similar porous titanium constructs compared to solid titanium surfaces⁹

In-vivo studies with similar porous titanium materials show that bony in-growth is increased at the 500-700 μm pore size range compared to larger or smaller pores^10-12
The porosity of cancellous human bone is typically 50-90%¹³
Based on this published science, CONDUIT™ Implants are designed with 80% porosity and 700 μm pore size^2,14

NANOSTRUCTURE

Similar titanium materials with nanoscale features have shown in in-vitro studies to lead to increased osteoblast adhesion when compared to conventional titanium materials¹⁵

All CONDUIT Implants undergo acid etching and heat treatment to promote micro-and nanoscale surface roughness¹

EXCELLENT VISUALIZATION

Ability to clearly visualize the cage intra-and post-operatively on imaging modalities without interference^3,4

80% porosity²:

High radiographic visibility allows for better contouring, endplate-implant contact evaluation and absence of tantalum marker scattering intra-and post-operatively
Clear visualization of the implant on X-Ray, absence of scattering on CT Scan and diminished artifacts in MRI^3,4

TARGETED MODULUS OF ELASTICITY

Modulus of Elasticity similar to cancellous bone^5,6 Proprietary 3D printing technology leads to cellular design that offers Modulus of Elasticity of titanium similar to bone⁵

Highly porous surface area and implant footprint variety that allows for maximum endplate-implant contact¹⁶

Videos

References

DePuy Synthes. SEM Report. 2019. ADAPTIV #103546250
Emerging Implant Technologies. Validation of Strut Diameter Summary. 2016. EOS. VAL2016-043.
Emerging Implant Technologies. Lumbar Implants Imaging Overview. 2016. EOS. 20102016-Rev.C
Emerging Implant Technologies. Cervical Implants Imaging Overview. 2016. EOS.
Youngs Modulus comparison of various materials GUM00001 rev A/ VAL 2017-007
Wolff J. “The Law of Bone Remodeling”. Berlin Heidelberg New York: Springer, 1986 (translation of the German 1892 edition)
Olivares-Navarrete R, Gittens RA, Schneider JM, et al. Rough titanium alloys regulate osteoblast production of angiogenic factors. Spine J 2012; 12:265-272
Lincks, J. et al. Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials 19, 1998. Pages 2219-32
Cheng A, Cohen D, Boyan B et al. Laser-Sintered Constructs with Bio-inspired Porosity and Surface Micro/ Nano-Roughness Enhance Mesenchymal Stem Cell Differentiation and Matrix Mineralization In Vitro. Calcif Tissue Int 2016; 99:625 -637
Wu S-H, Li Y, Zang Y-Q, et al. Porous Titanium-6 Aluminum-4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly-Ether-Ether-Ketone Cage in Sheep Vertebral Fusion. Art Organs 2013; 37:191-201
Taniguchi N, Fujibayashi S, Takemoto M, Sasaki K, Otsuki B, Nakamura T, Matsushita T, Kokubo T, Matsuda S. Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment. Materials Science and Engineering 2016; C59: 690 -701
Fukuda A, Takemoto M, Saito T, et al. Osteoinduction of porous Ti implants with a channel structure fabricated by Selective Laser Melting. Acta Biomat 2011; 7:2327-2336.
Bostrom M, Boskey A, Kaufman J, Einhorn T. Form and function of bone. In: Orthopaedic Basic Science Biology and Mechanics of the Musculoskeletal System. 2nd ed. Rosemont, IL: AAOS; 2000: 320-369
Emerging Implant Technologies. Scaffold Characteristics. 2018. EOS. P773 \
Webster TJ and EjioforJU. Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V and CoCrMo. Biomat 2004; 25:4731-4739
Emerging Implant Technologies. EIT Implant Sizes. 2018. EOS. Drawing 12028.05.108.

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