ETHICON™ 4000 Stapler System
Our latest innovation in laparoscopic stapling, the ETHICON™ 4000 Stapler and ETHICON™ 3D Reloads are designed to manage tissue complexities for the most secure staple line yet.1 Featuring proprietary 3D Stapling Technology for more evenly distributed pressure designed to reduce leaks and bleeds at the staple line.2A
About this device
The ETHICON™ 4000 System is engineered for strength and stability to deliver more consistent staples, from the first staple to the last.1,3B The enhanced design enables expanded tissues ranges and streamlined reload options to simplify reload choice.4C
Specialties
Colorectal, Thoracic, Bariatric, Urologic, General
Procedures
LAR, Colectomy, Lobectomy, Wedge Resection, Segmentectomy, Sleeve Gastrectomy, Gastric Bypass, Revisions, Hepatobiliary
Staple line integrity
Proprietary 3D Stapling Technology leads to fewer leak pathways.2D The ETHICON™ 4000 System features proprietary 3D staples with offset staple legs that more evenly distribute pressure throughout the staple line vs traditional 2D B form staples.2A It demonstrated:
- Improved leak resistance with 23% fewer staple line interventions5E
- More consistent staple form, from the first staple to the last1,3B
- Exceptional staple line integrity across the broadest range of tissue thicknesses1,6F
Real-world evidence
Since 2017, the use of ETHICON™ Surgical Stapling devices have demonstrated an association with improved clinical outcomes across varied tissue types, patient populations and countries.
- 47,000+ patients
- 700+ hospitals
- 14 studies across 9+ countries and 4 continents
Features & benefits
3D stapling technology
More evenly distributed pressure designed to reduce leaks and bleeds at the staple line2A
Engineered for strength and stability
Deliver more consistent staples, from the first staple to the last1,3B
Expanded tissue ranges
Streamlined reload options simplify choice4C
Learn how to use this device
Supporting documentation
Related products
ECHELON™ 3000 Stapler
The ECHELON™ 3000 Stapler was designed to accommodate each patient's unique anatomy, providing consistency across every staple line. It enables better access1A and more control2B over each transection, making it easier to tailor procedures to your patient's unique needs.
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ECHELON ENDOPATH™ Staple Line Reinforcement
Experience easy application for OR efficiency with our ECHELON ENDOPATH™ Staple Line Reinforcement (SLR). It is designed to stay in place during tissue manipulation1,2A and features an added layer of protection to reinforce the staple line, helping keep your focus squarely on the patient and procedure.
ECHELON™+ Stapler with GST Reloads
The ECHELON™+ Stapler is a powered laparoscopic stapler with exceptional staple line integrity across the broadest range of tissue thicknesses.1,2A It advances staple line security to deliver fewer leaks at the staple line and better staple formation, even in challenging conditions.3,4B
References
A. Finite element analysis found a 37% increase in staple line area for ETHICON™ 3D Reloads compared to ECHELON ENDOPATH™ Reloads with GST. Evaluation of leakage pathways. ETHICON™ 3D Reload (ER60B) had less leak pathway area at 0.302 in2 compared to ECHELON ENDOPATH™ GST Reload (GST60B) at 0.401 in2.
B. Consistency is defined as reduced staple height variation along the staple line. This is measured by the range of average delta from nominal staple height within the functional zone (in mm): ETHICON™ 3D Reloads (0.0128 - 0.0242); Tri-Staple™ Reloads (0.0403 - 0.0720).
C. The tissue range of ETHICON™ 3D Reloads is expanded compared to the ECHELON ENDOPATH™ GST Reloads.
D. Evaluation of leakage pathways. ETHICON™ 3D Reload (ER60B) had less leak pathway area at 0.302 in2 compared to ECHELON ENDOPATH™ GST Reload (GST60B) at 0.401 in2.
E. Evaluation of leakage resistance: ETHICON™ 3D Reload (ER60B) had less leak pathway area at 0.302 in2 than ECHELON ENDOPATH™ GST Reload (GST60B) at 0.401 in2. Intervention comparison based on retrospective comparative analysis of hemostasis performance in a porcine model for the ETHICON™ 4000 Stapler with 3D Reloads (EC3D60C & ER60W) vs. the ECHELON™ 3000 with GST Reloads (ECH60C & GST60W), n=114.
F. Exceptional staple line integrity based on staple form quality assessment for ETHICON™ 3D Reloads (ER60W/B/G/T). Tissue thickness range comparison: ETHICON™ 3D reloads (maximum 4.0mm) versus Tri-Staple™ reloads (maximum 3.0mm).
- Johnson & Johnson and its affiliates. Ethicon™ 4000 with Ethicon™ 3D Reloads – Staple Performance Claims. February 2024. Windchill # 502188145
- Johnson & Johnson and its affiliates. Evaluation of Leak Pathways for Claims: Echelon 4000 with 3D Reloads vs Echelon 3000 Stapler with GST. November 2024. Windchill # 502123426
- Global Business Insights. JJMT Market & Share 4Q'24 WW Surgery. March, 2025
- Johnson & Johnson and its affiliates. Project Royal Thick Tissue Investigation. July 2024. Windchill # 502031130
- Johnson & Johnson and its affiliates. Project Royal Retrospective Analysis: Hemostasis Performance Evaluation of Royal Stapler with Royal 3D 60 mm White Reload Compared to the ECHELON™ 3000 Stapler with 2D Gripping Surface Technology 60 mm White Reload in Non-Survival Swine Gastroepiploic Models. January 2025. Windchill #PRE 24-0058
- Medtronic Tri-Staple™ Reload. Intended Tissue Thickness Range. Document #P100153.
For complete indications, warnings, precautions, and adverse reactions, please reference full package insert.
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