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EARLY INTERVENTION
MONOVISC® High Molecular Weight Hyaluronan
Is a single-injection right for your knee OA patients and your practice?
MONOVISC® High Molecular Weight Hyaluronan is indicated for treatment of pain from Osteoarthritis (OA) of the knee. It is an FDA approved treatment made from ultra-pure hyaluronan. Hyaluronan is a natural chemical found in the body. The body's own hyaluronan acts like a lubricant and a shock absorber in the joint.
MONOVISC® is applicable to the USA only. Please refer to product safety information below.

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For all products, please refer to the instructions for use for a complete list of indications, contraindications, warnings and precautions.
Important Safety Information
MONOVISC High Molecular Weight Hyaluronan is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and to simple analgesics, e.g., acetaminophen. In clinical studies, the most commonly reported adverse events were arthralgia, joint swelling and injection site pain. MONOVISC is contraindicated in patients with known hypersensitivity to hyaluronate formulations or known hypersensitivity (allergy) to gram positive bacterial proteins. MONOVISC should not be injected in patients with infections or skin diseases in the area of the injection site or joint. MONOVISC should not be administered to patients with known bleeding disorders. Intra-articular injection of sodium hyaluronate preparations has occasionally been associated with allergic/anaphylactic reactions and transient hypotension, which have generally resolved spontaneously or after conservative treatment.
Footnotes:
+Studies showed no added long-term tension at tested loads (20N, 40N)
*Animal and bench testing results may not necessarily be indicative of clinical performance
References:
- Amjadi, M. and Fatemi, A., 2021. Creep behavior and modeling of high-density polyethylene (HDPE). Polymer Testing, 94(0142-9418) p. 107031. https://doi.org/10.1016/j.polymertesting.2020.107031.
- Estupinan, J.E., Baldini, T.H., Bartel, D.L., Wright, T.M. Recoverable and Irrecoverable Creep of UHMWPE. Paper presented at: 45th Annual Meeting of the Orthopaedic Research Society; February 1-4, 1999; Anaheim, CA.
- Connaughton, A.J., et al. All-inside ACL reconstruction: How does it compare to standard ACL reconstruction techniques?. Journal of Orthopaedics 14 (2017)241-246.
- DYNACORD Suture Approximation Force Report. ADAPTIV #103394861.
- DYNATAPE Suture Approximation Force Report. ADAPTIV #103670396.
196140-211117 DSUS