A Growing Epidemic:

A Growing Epidemic:

Atrial Fibrillation (AFib)

AFib is an irregular heart rhythm that is quickly placing critical burden on patients and healthcare systems.

43 Miillion people are impacted by Atrial Fibrillation globally. 7 million in the United States. 2 million iin Latin America. 14 million in Europe. 20 million in Asia-Pacifiic. (World Map)
Doughnut chart indicating 32% of global deaths caused by cardiovascular disease.

32% of global deaths are caused by cardiovascular disease.1
85% of these deaths were due to heart attack and stroke, and AFib increases the risk for stroke.1,3

Bulleted list indicating conditions that Atrial Fibrillation can lead to: 1. Heart failure 2. Stroke 3. Death (cardiovascular mortality)

If left untreated, AFib can lead to other conditions3.

Line chart showing upward moving line indicating 33% increase.

The worldwide prevalence of AFib has increased by 33% during the last 20 years4, placing a huge burden across the globe.

AFib in Asia-Pacific

AFib currently effects2:

In China, Atrial Fibrillation affects over 13 million people. (Map)
In India, Atrial Fibrillation affects 7 million people. (Map)
In Taiwan, Atrial Fibrillation affects 259 thousand people. (Map)
In Australia, Atrial Fibrillation affects 521 thousand people. (Map)
In Japan, Atrial Fibrillation affects 1 million people. (Map)
In Korea, Atrial Fibrillation affects 319 thousand people. (Map)
Three arrows pointing up in ascending height order.

By 2050, AFib is expected to affect 72 Million people,5,6 

That's more than twice as many AFib patients as Europe and North America combined.

For healthcare systems across APAC, every 10 years there is a 1.8-5.6x increase in healthcare costs due to Afib.7,8,9,10,11

Atrial Fibrillation affects 14 million people across Europe. (Region Map)

By 2030, the number of people with AFib is expected to increase up to 70%.12

Bulleted list of countries where Atrial Fibrillation is as common as stroke and cancer: 1. France 2. Germany 3. Italy 4. United Kingdom

In these European nations, AFib is almost as common as stroke and cancer13.

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AFib increasingly places a critical financial burden on the healthcare system, costing €660-€3,286 million annually across European countries14,15,16,17,18

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It is estimated that up to 2.6% of total annual healthcare expenditure is associated with AFib in European countries.19

AFib in the United States Header (Map of US)

AFib prevalence is expected to increase by 30% by 2035.20

Yearly, AFib is the reason for:

Stroke Brain Icon

795k strokes21

AFib Heart Icon

479k new AFib hospitalizations21

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$35.7B in medical costs21

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537k ER visits22

Map of South American countries affected by Atrial Fibrillation: Mexico 417 Thousand Cases. Colombia 192 Thousand Cases. Brazil 1 Million Cases. Chile 138 Thousand Cases. Argentina 280 Thousand Cases.

AFib in Latin America
 

AFib affects2:

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AFib is one of the Top 4 cardiovascular diseases most common in Latin America23

Caution Sign: 2 Times higher risk icon

The rate of AFib-related strokes in South America is comparable to that of Western Europe and the U.S., however, the 1-year mortality risk was almost 2x as high.24,i

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In 2015, AFib had an economic burden estimated at $2.4 billion (USD) in LATAM.25

Overcoming AFib Heart Header

AFib is a progressive disease that may get worse over time so early diagnosis and treatment is essential for overcoming this global epidemic.

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Medications are often the first attempt at treating AFib, but if medications don’t work, catheter ablation is recommended.

Catheter ablation

A minimally invasive procedure performed by heart rhythm specialists that can improve your quality of life with the following benefits:

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Improvement in quality of life26

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Permanent symptom relief26

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Elimination of long-term risk of stroke and death normally associated with AFib27

more info on afib

References

  1. Cardiovascular diseases (CVDs) fact sheet. World Health Organization. June 11, 2021. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)  
  2. Institute for Health Metrics and Evaluation (IHME). Global Health Data Exchange. Seattle, WA: IHME, University of Washington. Available at http://ghdx.healthdata.org/gbd-results-tool. Location: Countries, Year: 2019, Context: cause, Age: all ages, Metric: number, Measure: prevalence, Sex: both, Cause: B.2.8. Atrial fibrillation and flutter. (Accessed August 24, 2021)  
  3. Odutayo A, Wong CX, Hsiao AJ, Hopewell S, Altman DG et al. (2016) Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta-analysis. Bmj 354 i4482.  
  4. Lippi G, Sanchis-Gomar F, Cervellin G. Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. Int J Stroke. 2021 Feb;16(2):217-221. doi: 10.1177/1747493019897870. Epub 2020 Jan 19. Erratum in: Int J Stroke. 2020 Jan 28;:1747493020905964. PMID: 31955707.  
  5. Wong CX, Brown A, Tse HF, et al. Epidemiology of Atrial Fibrillation: The Australian and Asia-Pacific Perspective. Heart Lung Circ. 2017;26(9):807-879  
  6. Chiang CE, Wang KL, Lip GY. Stroke prevention in atrial fibrillation; an Asian Perspective. Thromb Heamost. 2014;111(5)789-797  
  7. Gallagher C, Hendriks JM, Giles L, et al. Increasing trends in hospitalisations due to atrial fibrillation in Australia from 1993 to 2013. Heart. 2019.  
  8. Hu S, Zhan L, Liu B, et al. Economic Burden of Individual Suffering from Atrial Fibrillation-Related Stroke in China. Value Health Reg Issues. 2013;2(1):135-140.  
  9. Joung B, Lee JM, Lee KH, et al. 2018 Korean Guideline of Atrial Fibrillation Management. Korean Circ J. 2018;48(12):1033-1080.  
  10. Kim D, Yang PS, Jang E, et al. Increasing trends in hospital care burden of atrial fibrillation in Korea, 2006 through 2015. Heart. 2018;104(24):2010-2017.  
  11. Lee H, Kim TH, Baek YS, et al. The Trends of Atrial Fibrillation-Related Hospital Visit and Cost, Treatment Pattern and Mortality in Korea: 10-Year Nationwide Sample Cohort Data. Korean Circ J. 2017;47(1):56-64. 
  12. Zoni-Berisso M, Lercari F, Carazza T, Domenicucci S (2014) Epidemiology of atrial fibrillation: European perspective. Clin Epidemiol 6 213-220.  
  13. Global Burden of Disease Collaborative Network (2016) Global Burden of Disease Study 2016 (GBD 2016) Results. Seattle, United States: Institute for Health Metrics and Evaluation (IHME), 2017. Available from http://ghdx.healthdata.org/gbd-results-tool.  
  14. McBride D, Mattenklotz AM, Willich SN, Bruggenjurgen B (2009) The costs of care in atrial fibrillation and the effect of treatment modalities in Germany. Value Health 12 (2): 293-301.  
  15. Ball J, Carrington MJ, McMurray JJ, Stewart S (2013) Atrial fibrillation: profile and burden of an evolving epidemic in the 21st century. Int J Cardiol 167 (5): 1807-1824.  
  16. Cotte FE, Chaize G, Gaudin AF, Samson A, Vainchtock A et al. (2016) Burden of stroke and other cardiovascular complications in patients with atrial fibrillation hospitalized in France. Europace 18 (4): 501-507  
  17. Stewart S, Murphy NF, Walker A, McGuire A, McMurray JJ (2004) Cost of an emerging epidemic: an economic analysis of atrial fibrillation in the UK. Heart 90 (3): 286-292.  
  18. Ringborg A, Nieuwlaat R, Lindgren P, Jonsson B, Fidan D et al. (2008) Costs of atrial fibrillation in five European countries: results from the Euro Heart Survey on atrial fibrillation. Europace 10 (4): 403-411.  
  19. Velleca, Maria, Costa, Grace, et al. A Review of the Burden of Atrial Fibrillation: Understanding the Impact of the New Millennium Epidemic Across Europe. EMJ Cardiol.. 2019;7[1]:110-118.  
  20. Khavjou, Olga, D. Phelps, and A. Leib. “Projections of cardiovascular disease prevalence and costs: 2015–2035.” Dallas: American Heart Association (2016).  
  21. Mozaffarian, Dariush, et al. “Heart disease and stroke statistics—2016 update: a report from the American Heart Association.” Circulation (2015)  
  22. Rozen, Guy, et al. “Emergency Department Visits for Atrial Fibrillation in the United States: Trends in Admission Rates and Economic Burden From 2007 to 2014.” Journal of the American Heart Association 7.15 (2018): e009024. 
  23. El costo de las enfermedades cardiacas en América Latina. World Health Federation. Congreso Mundial de Cardiología y Salud Cardiovascular (WCC 2016)  
  24. Cubillos L, Haddad A, Kuznik A, Mould-Quevedo J. Burden of disease from atrial fibrillation in adults from seven countries in Latin America. Int J Gen Med. 2014;7:441-448.  
  25. Stevens, B., Verdian, L. et al. The Economic Burden of Atrial Fibrillation in Latin America. Value in Health. 2016; Vol 9, Issue 7. https://doi.org/10.1016/j.jval.2016.09.1726 Published 2014 Sep 2. doi:10.2147/IJGM.S62819  
  26. Hugh Calkins, Gerhard Hindricks, Ricardo Cappato, et al. 2017 HRS/EHRA/ECAS/AP HRS/SOLAECE expert consensus statement on catheter ablation and surgical ablation of atrial fibrillation. 2017.  
  27. De Greef Y, Schwagten B, Chierchia GB, De Asmundis C, Stockman D, Buysschaert I. Diagnosis-to-ablation time as a predictor of success: Early choice for pulmonary vein isolation and long-term outcome in atrial fibrillation: Results from the Middelheim-PVI Registry
  1. Based on limited country data reporting.

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