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Clot Characterization
Modeling Diverse Clots that Cause Stroke
Clots that cause stroke can come from numerous sources in the body, and they differ in composition, age, and morphology. NTI has developed methods to create a wide range of clot analogs that reflect clinical clots, in order to better understand these challenges in treating ischemic stroke.

Fresh thrombus encapsulating mature fibrin core

Young erythrocyte-rich clot analogue

Partially matured clot analogue

Heterogeneous clot with erythrocyte-rich and fibrin rich regions

Layered clot with mature fibrin base and fresh erythrocyte deposition

Composite clot with calcific inclusion

Highly organized fibrin-rich clot analogue

Fresh, erythrocyte-rich clot analogue

Shear-induced fibrin-rich prosthetic valve clot analogue
Staining of four different clot types (x20 magnification). MSB stained fibrin red and erythrocytes yellow:
H&E (hematoxylin and eosin staining)
MSB (martius scarlet blue staining)

Clot replete with red blood cells (RBCs)

Thrombin induced clot predominately composed of RBCs with interspersed bands of fibrin

Dynamically formed clot, demonstrating a predominance of fibrin with collections of RBCs

Fibrin rich clot, showing delicate fine fibrin strands
Duffy S, et al. J NeuroIntervent Surg 2016;0:1–7.
Clot-Device Interaction
Advancing the Understanding of Clot-Device Interaction
Multiple clot properties change with clot-device interaction. One example is that as a clot undergoes compression, the coefficient of friction and resistance to retrieval increases.
Clot Compression Increases Resistance
NTI research collaborations are exploring an extensive set of properties and implications related to clot-device interaction.
Education Grant Support
For assistance with the submission of Educational Grant requests: https://www.totalitygrants.com/site/165W/BWI/MDD
References
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