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Clinical Evidence
Clinical Evidence
The Colorectal NEXT program aims to improve patient
outcomes and reduce the burden of anastomotic leaks.
On this page you will find evidence supporting the program.
New Harmonic Scalpel versus Conventional Haemostasis in Right Colon Surgery: A Prospective Randomised Controlled Clinical Trial
Sista F, Abruzzese V, Schietroma M, et al. Dig Surg. 2013;30(4–6):355–361
Study Conclusion:
HARMONIC ultrasonic device reduces operative time and blood and lymphatic loss, and allows satisfactory maintenance of protein storage, resulting in a lower incidence of complications and faster patient recovery following right colon surgery. For these reasons the HARMONIC ultrasonic device should be used routinely in colon surgery.
Assessment of a Circular Powered Stapler for Creation of Anastomosis in Left-sided Colorectal Surgery: A Prospective Cohort Study
Herzig DO, Ogilvie JW, Chudzinski A. Int J Surg. 2020;84:140–146.
Study Conclusion:
The ECHELON CIRCULAR Powered Stapler has a favourable safety profile and is an effective device for left-sided colon anastomoses, with high surgeon satisfaction for ease of use compared to mechanical circular staplers and few clinically relevant performance issues
Outcomes Associated with the Use of a New Powered Circular Stapler for Left‑sided Colorectal Reconstructions: A Propensity Score Matching‑adjusted Indirect Comparison with Manual Circular Staplers
Sylla P, Sagar P, Johnston SS, et al. Surg Endosc. 2022;36(4):2541-2553.
Study Conclusion:
The ECHELON CIRCULAR Powered Stapler has a favourable safety profile with lower rates of surgical complications, such as anastomotic leak, and a lower rate of 30-day readmission as compared to conventional manual circular staplers
Clinical Experience with the Use of the CONTOUR Curved Cutter Stapler in Colorectal Surgical Procedures: A Systematic Literature Review
Lim S, Clymer JW, Roy S. J Surg. 2018;1130.
Study Conclusion:
The CONTOUR Curved Cutter Stapler offers superior tissue preservation and lower rates of certain complications, such as pelvic contamination, compared to conventional staplers in open and laparoscopic colorectal procedures
ECHELON CIRCULAR Powered Stapler
In an independent clinical study, the ECHELON CIRCULAR™ Powered Stapler demonstrated an 85% reduction in anastomotic leak rates compared to manual circular staplers (1.7% vs. 11.8%, p=0.02).1a
Influence of Multiple Stapler Firings Used for Rectal Division on Colorectal Anastomotic Leak Rate
Braunschmid T, Hartig N, Baumann L et al. Surg Endosc. 2017;31(12):5318-5326.
Study Conclusion:
An important risk factor for anastomotic leak during colorectal resection is the use of multiple stapler firings during rectal division
An Assessment of the Clinical and Economic Impact of Establishing Ileocolic Anastomoses in Right-colon Resection Surgeries Using Mechanical Staplers Compared to Hand-sewn Technique
Roy S, Ghosh S, Yoo A. Surg Res Pract. 2015;749186.
Study Conclusion:
Mechanical stapling can be considered as a clinically and economically favourable option (in terms of AL rates, reoperation rates, OR time and hospital costs) compared to hand suturing for establishing anastomoses in patients undergoing right colon surgery
The Clinical and Economic Value of Triclosan-coated Surgical Sutures in Abdominal Surgery
Ceresoli M, Carissimi F, Piemontese A, et al. Appl Sci. 2020;10(3):1090.
Study Conclusion:
The use of triclosan-coated sutures results in significant and robust cost savings, according to the economic cost model developed in this study. Triclosan-coated sutures should be considered for wound closure as a cost-saving measure to prevent SSIs
Standardisation of Surgical Procedures to Reduce Risk of Anastomotic Leakage, Reoperation, and Surgical Site Infection in Colorectal Cancer Surgery: A Retrospective Cohort Study of 1,189 Patients
Eto K, Urashima M, Kosuge M, et al. Int J Colorectal Dis. 2018;33(6):755-762
Study Conclusion:
Standardisation of colorectal surgery using a laparoscopic approach, combined with triangulating anastomosis for colon surgery, and defunctioning ileostomy for low anterior resection, lowered the risk of anastomotic leak, reoperation and surgical site infection
Complications in Colorectal Surgery: Risk Factors and Preventive Strategies A Literature Review
Kirchhoff P, Clavien P-A, Hahnloser D. Patient Saf Surg. 2010 Mar 25;4(1):5.
Study Conclusion:
In order to minimise or even avoid complications it is crucial for surgeons to know the risk factors and strategies used to prevent, treat or reduce intra- and postoperative complications
The “Sphere of Care”: A Qualitative Study of Colorectal Cancer Patient and Caregiver Experiences of Support Within the Cancer Treatment Setting
Law E, Levesque JV, Lambert S, Girgis A. PloS One. 2018;13(12):e0209436
Study Conclusion:
Both patients and their caregivers highly value positive relationships with healthcare professionals during treatment of colorectal cancer. Competence, kindness and compassion underpin these relationships, and can be strengthened by enhancing communication skills through a dedicated program and developing pathways that support patients and caregivers within their treatment context
Implementing a Timed Colorectal Cancer Diagnostic Pathway A handbook for Local Health and Care Systems
NHS England. 2018.
Study Conclusion:
A colorectal cancer diagnostic pathway which engages with patients, maximises use of existing facilities and supports new ways of working among medical staff can be achieved. This can lead to patient-, workforce- and system-centric benefits, including improved quality of care and less variable outcomes
Cost-effective Commissioning of Colorectal Cancer Care: An Assessment of the Cost Effectiveness of Improving Early Diagnosis A National Guideline and Literature Review
Public Health England. 2016; 2016359.
Study Conclusion:
Early diagnosis within the colorectal cancer pathway can lead to better clinical outcomes and improved cost-effectiveness as measured by indicators such as 5-year patient survival rate
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